Feline Kidney Mensuration

Feline Chronic Kidney Disease

36 Chronic kidney disease (CKD) affects an estimated 1% to 3% of all cats.1 This important cause of mortality in cats develops over a period of months or years. The associated nephron damage is progressive and irreversible even though some cats with CKD have stable serum creatinine concentrations for months to years. Diagnosis of early CKD, followed by appropriate treatment, may result in impro...

Video Mensuration Using a Stationary Camera

Attachment and internalization of feline infectious peritonitis virus in feline blood monocytes and Crandell feline kidney cells.

In this study, kinetics of attachment and internalization of feline infectious peritonitis virus (FIPV) serotype I strain Black and serotype II strain 79-1146 were determined in feline monocytes from two cats and in Crandell feline kidney (CrFK) cells. Attached FIPV I (Black) particles were observed on almost all monocytes. Within 1 h, 17 particles were bound per cell and, within 1 min, 89 % of...

A determinant of feline immunodeficiency virus involved in Crandell feline kidney cell tropism.

Viral progeny of the molecular clone 19k1 of feline immunodeficiency virus (FIV) can infect feline T-cells but not Crandell feline kidney (CrFK) cells. In contrast, the biological isolate FIV-AM6c, which was CrFK adapted by co-cultivation of FIV-AM6 infected thymocytes with CrFK cells, can infect both thymocytes and CrFK cells. The envelope gene of FIV-AM6c was amplified by polymerase chain rea...

Feline polycystic kidney disease mutation identified in PKD1.

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder in humans that causes the formation of fluid-filled renal cysts, often leading to renal failure. PKD1 mutations cause 85% of ADPKD. Feline PKD is autosomal dominant and has clinical presentations similar to humans. PKD affects approximately 38% of Persian cats worldwide, which is approximately 6% of cats, maki...